United States securities and exchange commission logo





                          November 13, 2023

       Antony Mattessich
       President and Chief Executive Officer
       Ocular Therapeutix, Inc.
       24 Crosby Drive
       Bedford, MA 01730

                                                        Re: Ocular Therapeutix,
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed November 7,
2023
                                                            File No. 333-275373

       Dear Antony Mattessich:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Alan
Campbell at 202-551-4224 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              C.S. Avery Reaves, Esq.